Department of Toxicology


Selected published articles

Read: 950

 

2011

  • Bajgar, J. et al. Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo. J. Appl. Biomed. 2011, 9, 35.
  • Kassa, J.; Zdarova-Karasova, J.; Pavlikova, R.; Musilek, K.; Kuca, K.; Bajgar, J.; Jung, Y.-S. A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicol. Mech. Meth. 2011, 21, 241.
  • Musilek, K.; Roder, J.; Komloova, M.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Opletalova, V.; Kuca, K.; Jung, Y.-S. Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors—Analogues of SAD-128. Bioorg. Med. Chem. Lett. 2011, 21, 150.
  • Musilek, K.; Komloova, M.; Holas, O.; Horova, A.; Pohanka, M.; Gunn-Moore, F.; Dohnal, V.; Dolezal, M.; Kuca, K. Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage – Preparation, in vitro screening and molecular docking. Bioorg. Med. Chem. 2011, 19, 754.
  • Musilek, K.; Komloova, M.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Nachon, F.; Dolezal, M.; Kuca, K. Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – implications for early Myasthenia gravis treatment. Eur. J. Med. Chem. 2011, 46, 811.
  • Musilek, K.; Pavlikova, R.; Komloova, M.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Dolezal, M.; Kuca, K. Preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors bearing but-(2E)-en-1,4-diyl connecting linkage. J. Enzym. Inhib. Med. Chem. 2011, 26, 245.
  • Pohanka, M.; Sobotka, J.; Stetina, R. Sulfur mustard induced oxidative stress and its alteration by epigallocatechin gallate. Toxicol. Lett. 2011, 201, 105.
  • Zdarova-Karasova, J.; Zemek, F.; Bajgar, J.; Vasatova, M.; Prochazka, P.; Novotny, L.; Kuca, K. Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain. J. Pharm. Biomed. Anal. 2011, 54, 1082.

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